Yu Zhu

Yu Zhu

BSc Candidate of Bioinformatics

Soochow University

Biography

Yu Zhu is an undergraduate student majoring in Bioinformatics at Soochow University, China since 2018.

Under the guidance of Assoc. Prof. Guang Hu and Assoc. Prof. Zhongjie Liang, he is now focusing on how to integrate bioinformatics and biophysics methods to have an insight into protein dynamics, along with protein sequence, structure and function research and finally figure out how to use structural information for the construction and analysis of protein-protein interaction networks, paving the way for drug discovery. Also, supervised by Prof. Bairong Shen at Institutes for Systems Genetics, West China Hospital, he established a risk factor knowledgebase for neurodegenerative diseases (NDDRF) together with other group members.

Download Personal CV here.

Interests
  • Computational Biology
  • Systems Biology
  • Structure Bioinformatics
  • Biological Network
  • Bioinformatics Algorithm
  • Sequence Conservation
  • Proteome Informatics
  • Allosteric Drug Design
  • Database
Education
  • BSc in Bioinformatics, 2018 - Present

    Soochow University, China

Skills

Python

Commonly used programming language

R

Commonly used programming language

Unix/Linux-based platform

Commonly used operating system

Database & Web Page

Establishment of biological database and web page

Genome & Transcriptome & Proteome Informatics

Multi-scale bioinformatics analysis

Bioinformatics Algorithms

Algorithms related to biological data processing, network topology, machine learning …

Research Experiences

 
 
 
 
 
Allosteric Drug Design Targeting DNMT1 Protein-Protein Interactions (PPIs)
May 2020 – Present Suzhou, China

Supervised by: Assoc. Prof. Guang Hu and Assoc. Prof. Zhongjie Liang

Responsibilities include:

  • Construct the biological network of the complex, and develope indicators that quantitatively characterize the characteristics of the mutant residues
  • Predict the allosteric site and allosteric path of the complex based on perturbation response scanning (PRS) analysis
  • Explore pocket information in the trajectory of DNMTs, evaluate their targetability, and determine potential allosteric sites combining mutation information
 
 
 
 
 
Structural and Functional Analysis of Non-Small Cell Lung Cancer (NSCLC) Disease Modules
Oct 2019 – Oct 2020 Suzhou, China

Supervised by: Assoc. Prof. Guang Hu and Assoc. Prof. Zhongjie Liang

Responsibilities include:

  • Obtain the NSCLC-related disease network module from the pre-omics analysis
  • Carry out research in five aspects, including functional enrichment analysis, structural modeling of protein interactions, mapping of mutation and post-translational modification information and druggability based on drug pockets
  • Verify the pathogenic function of the NSCLC network module at the two levels of pathway and structure
 
 
 
 
 
Medical Research on Glycobiology, Glycomics and Glycobioinformatics
Jul 2020 – Aug 2020 Chengdu, China

Supervised by: Prof. Bairong Shen

Responsibilities include:

  • Sort out the subject development process of glycomics, glycobiology, and glycobioinformatics, and learned about the forefront progress of the subject.
  • Participate in several summit forums discussing frontier science in bioinformatics
 
 
 
 
 
Construction of Risk Factors Knowledgebase for Neurodegenerative Diseases (NDDRF knowledgebase)
Jul 2019 – Aug 2019 Chengdu, China

Supervised by: Prof. Bairong Shen

Responsibilities include:

  • Learn about the application of bioinformatics-related tools and database, and the data processing method of multi-omics analysis
  • Join Prof. Shen Bairong’s research group, and take charge of data mining and cleaning for more than ten neurodegenerative diseases
  • Establish the risk factors database for neurodegenerative diseases (NDDRF) together with other group members
  • Follow up with the latest research progress in bioinformatics, and participate in academic conferences

Honors and Awards

Year 2021
  • The Second Prize in the First “Zhaoyin” Cup Financial Mathematical Modeling Competition
  • The Third Prize for Band C in 2021 National English Competition for College Students
  • The Second Prize in the 22nd “Challenge Cup” Medical College of Soochow University Undergraduate Curricular Academic Science and Technology Works Competition
  • National Scholarship
  • Comprehensive Scholarship
  • Merit Student
  • The Special Scholarship for Innovation and Entrepreneurship
  • The Special Prize Scholarship for Academic Excellence
Year 2020
  • The First Prize Scholarship for Academic Excellence
  • Comprehensive Scholarship
  • The Special Scholarship for Innovation and Entrepreneurship
  • Merit Student
  • Scientific and Technological Innovation Star of Medical College
Year 2019
  • The First Prize for Academic Excellence
  • Comprehensive Prize
  • Merit Student
  • The Special Prize for Spiritual Civilization
  • Excellent Volunteer Team
  • Excellent Summer Social Practice Team

Posts

Publications

Contact

  • yzhu99@stu.suda.edu.cn
  • Soochow University Dushu-Lake Campus, Suzhou, Jiangsu Province 215000
  • Department of Bioinformatics, Center for Systems Biology
  • Yu Zhu